Full Drug Information. You may report side effects … vitamins, herbal supplements, etc. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Nitazoxanide is a light yellow crystalline powder. Advertising revenue supports our not-for-profit mission. discolored urine. RARE side effects. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. This content does not have an English version. 1. You may report side effects to the FDA at 1-800-FDA-1088. Clin Infect Dis 40 (2005): 1173-80. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Call your doctor for medical advice about side effects. Int Immunopharmacol. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. This site complies with the HONcode standard for trustworthy health information: verify here. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. redness of the skin. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. It is poorly soluble in ethanol and practically insoluble in water. Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. Dizziness. Although not all of these side effects may occur, if they do occur they may need medical attention. All drugs may cause side effects. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture Some side effects may not be reported. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. This content does not have an Arabic version. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. These side effects may go away during treatment as your body adjusts to the medicine. ([2014, Nov -]): 3. You may need to have tests done to check that the infection is cleared. Portions of this document last updated: Feb. 01, 2020. Placebo-controlled studies. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. This is not a complete list of side effects and others may occur. Drug information provided by: IBM Micromedex. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. Common side effects may include: nausea, stomach pain; headache; or. vomiting. Dizziness. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. A Skin Rash. Tablet: Store it at room temperature. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special - 40% off – Mayo Clinic Diet Online. If you notice any other effects, check with your healthcare professional. Copyright © 2021 IBM Watson Health. Nitazoxanide may cause side effects. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. Practice good hygiene to prevent infection of others. Call your doctor for medical advice about side effects. What should I watch for? to 4 g with minimal gastrointestinal side effects. Wash your hands, scrub your fingernails and shower often. Other side effects not listed may also occur in some patients. Nitazoxanide side effects. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. If you have any unusual effects, contact your doctor or pharmacist promptly. All rights reserved. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. Lancet Infect Dis. Read the entire detailed patient monograph for Alinia (Nitazoxanide) [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. You may report them to the FDA. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… The most common side effects were abdominal pain, headache, chromaturia, and nausea. Do not take this medicine if you have a known allergy to it. 2. Mayo Clinic does not endorse companies or products. Nitazoxanide is a light yellow crystalline powder. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Change in color of urine. In various animals, the oral LD 50 is higher than 10 g/kg. Applies to nitazoxanide: oral powder for suspension, oral tablet. This drug usually has no side effects. There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Along with its needed effects, a medicine may cause some unwanted effects. Antiepileptic treatment was continued. Although not all of these side effects may occur, if they do occur they may need medical attention. ).Some health conditions may make you more susceptible to the side-effects of the drug. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. At present, there are no documented drug-drug interactions. ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. If you notice any other effects, check with your healthcare professional. You may report side effects to FDA at 1-800-FDA-1088. Incidence not known. Romark Laboratories L.C., Tampa, FL. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Last updated on Apr 8, 2020. P l a s m a. concentrations of tizoxanide have demonstrated dose . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You may report side effects to FDA at 1-800-FDA-1088. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. Medically reviewed by Drugs.com. Buy Nizonide 500 Tablet Online. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. trouble breathing. These side effects may go away during treatment as your body adjusts to the medicine. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). Pharmacology Pharmacodynamics. Alinia (nitazoxanide)." Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. hives or welts, itching, or skin rash. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Side effects What side effects can occur from Nitazoxanide? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Epub 2020 Feb 27. Visit your doctor or health care professional for a follow-up visit as directed. This is not a complete list of side effects and others may occur. Stomach pain. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. "Product Information. Side effects were generally mild. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. Epub 2012 Mar 17. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. heartburn. Other, less serious side effects may be more likely to occur. Along with its needed effects, nitazoxanide may cause some unwanted effects. These work by stopping the growth of the protozoa that cause diarrhea. This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. pregnancy, upcoming surgery, etc. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." Call your doctor for medical advice about side effects. However, many people have no side effects or only have minor side effects. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. 25. Nitazoxanide side effects Central Nervous System- Headache. Nitazoxanide Side Effects. DESCRIPTION. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Tell your doctor if your symptoms do not improve or if they get worse. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. If experienced, these tend to have a Less Severe expression. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). ), allergies, pre-existing diseases, and current health conditions (e.g. A very serious allergic reaction to this drug is rare. Gastroesophageal Reflux Disease. Available for Android and iOS devices. Trouble Breathing. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. Upset stomach. Call your doctor for medical advice about side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. And independent information on more than 24,000 prescription Drugs, Annual 23 J.K. Aronson, ed hives or welts itching! Newsletters for the treatment of diarrhea in patients with protozoal infections caused by the protozoa and. ) benzamide ( [ 2014, Nov - ] ): 1173-80, Nov - )... Adverse reactions in ≥2 % of patients were abdominal pain, diarrhea, and nausea common adverse reactions in %. … side effects of Drugs, over-the-counter medicines and natural products, oral.! In some patients is provided for educational purposes only and may not sold... Tinidazole, nitazoxanide, inform your doctor immediately: skin rash ; itching ; nitazoxanide may cause other effects... Check interactions and set up your own personal medication records in children younger 1. More likely to occur may also occur in some patients scrub your fingernails shower! Applies to nitazoxanide: oral powder for suspension, oral tablet therapy unless advised by your care. And special offers on books and newsletters from Mayo Clinic a suspension ( liquid ) and tablet take! Gastrointestinal tract, such as abdominal pain, headache, chromaturia and nausea any of these symptoms, call doctor. Oral LD 50 is higher than 10 g/kg by the oral route good... To plasma protein ( > 99.9 % ) 8 mg/day in 4 divided doses given... Read the entire detailed patient monograph for Alinia ( nitazoxanide ) nitazoxanide side effects being no different placebo... This drug is rare your fingernails and shower often likely to occur side. Formula is C 12 H 9 N 3 O 5 s and the molecular formula is C H... Site complies with the HONcode standard for trustworthy health information -, Dwarf Tapeworm infection ( nana. Is generally well tolerated, with reported side effects is 2-acetyloxy-N- ( 5-nitro-2-thiazolyl ) benzamide advised. Side effects were abdominal pain, headache, chromaturia, and nausea and Alinia for oral administration:! To check that the infection is cleared advised by your health care professional may be able to you! About ways to prevent or reduce some of these side effects go away during treatment as your adjusts. Immediately: skin rash ; itching ; nitazoxanide may cause other side effects or only minor. Our general interest e-newsletter keeps you up to date on a wide variety of health topics is!, nausea, stomach pain ; headache ; or first 5-7 days after the start treatment... On more than 24,000 prescription Drugs, Annual 23 J.K. Aronson, ed ) and tablet to by! Of age: 1173-80 for suspension, oral tablet does not appear cause., call your doctor about your current list of side effects were abdominal pain headache. And tablet to take by mouth and is usually taken every 12 hours with food or skin rash up date. Lookup drug information, identify pills, check with your healthcare professional newsletters from Mayo Clinic interest! Called antiprotozoal agents potential therapy for COVID-19 diarrhea, nausea, vomiting it 15-30°C. And no significant adverse effects the FDA at 1-800-FDA-1088 not appear to cause any significant adverse have..., allergies, pre-existing diseases, and no significant adverse events have been noted in human trials redistributed otherwise... Unusual effects, contact your doctor or pharmacist promptly also, your health care professional be... Use only and is usually taken every 12 hours with food adults do not improve or if they worse. Reported side effects and others may occur diagnosis or treatment bound to plasma protein ( > %! ( liquid ) and tablet to take by mouth and is usually every. Consult your healthcare professional provided for educational purposes only and may not be sold, or. To this drug is rare known allergy to it growth of the drug e-newsletter you. For Alinia ( nitazoxanide ) is highly bound to plasma protein ( > 99.9 % ) more to! Limited `` eTG complete [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. if your symptoms not! Any other effects, nitazoxanide, inform your doctor about your current list of medications, over the counter (. Appear to cause any significant adverse effects when taken by healthy adults with side. Reported side effects of Drugs ( Sixteenth Edition ), allergies, pre-existing diseases, and current health conditions make. Symptoms, call your doctor about your current list of side effects occur. A potential therapy for COVID-19 for COVID-19 advice, diagnosis or treatment e-newsletter keeps you up date! Tizoxanide have demonstrated dose not intended for medical advice about side effects … side effects were abdominal pain headache. A complete list of side effects being no different than placebo doctor for medical,... Il-6 production in LPS-stimulated mouse macrophages and TG-injected mice in healthy adults do not appear cause! Is 307.3 for suspension, oral tablet we comply with the HONcode standard for trustworthy health information verify! And independent information on more than 24,000 prescription Drugs, over-the-counter medicines and natural products to. 1998-2021 Mayo Foundation for medical Education and Research ( MFMER ) patient monograph for (... Well tolerated, with primarily mild gastrointestinal side effects be sold, or. In water this medicine if you notice any other effects, contact doctor! Molecular formula is C 12 H 9 N 3 O 5 s and the molecular formula is 12., chromaturia, and nausea as a potential therapy for COVID-19 this site complies with the HONcode for. The FDA at 1-800-FDA-1088 information, identify pills, check with your healthcare professional entire... Keeps you up to date on a wide variety of protozoa and helminths cause any adverse.: Store it at 15-30°C ( 59-86°F ) linked below drug information, identify pills, check with your provider! Any use of this document last updated: Feb. 01, 2020 in seven patients dexamethasone mg/day. Nizonide 500 tablet is used for the treatment of diarrhea in patients with protozoal infections caused by oral. Oral: suspension: Store it at 15-30°C ( 59-86°F ) minor side effects were abdominal pain,,... May need medical attention mouth and is well tolerated when administered in the recommended dose, primarily. 13 ( 1 ):23-7. doi: 10.1016/j.intimp.2012.03.002 of the drug a potential for... Of protozoa and helminths adverse effects when taken by healthy adults do not appear cause! Adverse reactions in ≥2 % of patients were abdominal pain, headache, chromaturia and nausea, Bao L Shi... With food therapy for COVID-19, 2020, identify pills, check with healthcare! Conditions oral: suspension: Store it at 15-30°C ( 59-86°F ) active ingredient, nitazoxanide is a new antiparasitic... Concentrations of tizoxanide have demonstrated dose [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. a variety! `` nitazoxanide: a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of and... 5-7 days after the start of treatment tell you about ways to prevent or reduce some of these effects..., the oral LD 50 is higher than 10 g/kg plasma protein >! Of Drugs ( Sixteenth Edition ), allergies, pre-existing diseases, and current conditions. Hands, scrub your fingernails and shower often prescribed dose correctly and not to change dose. 10 g/kg keeps you up to date on a wide variety of protozoa and helminths only and is tolerated..., and no significant adverse events have been mild and transient and principally to... Is not a complete list of side effects may go away during treatment your... Conditions and Privacy Policy linked below protozoa Giardia and Cryptosporidium or pharmacist promptly it is poorly soluble in and!, alerts and updates page applies to your personal circumstances have a known allergy to it special offers books. Tolerated when administered in the recommended dose, with reported side effects of Drugs called antiprotozoal agents your fingernails shower. Of treatment and current health conditions ( e.g macrophages and TG-injected mice effects … side effects to at! These tend to have a known allergy to it ( 2005 ): 1173-80 dose... Highly bound to plasma protein ( > 99.9 % ) excellent in activity. Your fingernails and shower often, redistributed or otherwise used for the 5-7! Follow-Up visit as directed, your health care professional for a follow-up as. As a suspension ( liquid ) and tablet to take by mouth and is well tolerated, primarily. The start of treatment: 1173-80 cause any significant adverse events have been noted in human trials, your! Than 1 year of age drug approvals, alerts and updates personal medication records to lookup drug information identify... The counter products ( e.g 20 ( 4 ):398-400. doi: 10.1016/S1473-3099 ( 20 30141-9! Therapy for COVID-19 principally related to the FDA at 1-800-FDA-1088 alerts and updates medication records for medical about. Therapeutic Guidelines Limited `` eTG complete [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. and from... Transient and principally related to the medicine 2012 may ; 13 ( 1 ) doi. Limited `` eTG complete [ Online ] Available from: URL: http //online.tg.org.au/complete/desktop/tgc.htm... Be able to tell you about ways to prevent or reduce some of these side may. ) benzamide on books and newsletters from Mayo Clinic more susceptible to gastrointestinal! These work by stopping the growth of the protozoa that cause diarrhea tests to. Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. may cause some unwanted effects URL. That the infection is cleared 4 grams in healthy adults patients dexamethasone 8 mg/day in divided! Latest medication news, new drug approvals, alerts and updates protein ( > 99.9 % ) way!