[42] In addition, subjective sleepiness correlated well with the brain H1 receptor occupancy. If you exceed with 2 or more there will be an effect on your son but taking too much can cause extremely blurred vision, rarely will it cause you to get high in a good way. Hallucinations is found among people who take Hydroxyzine, especially for people who are female, 50-59 old, have been taking the drug for < 1 month. View complete list of side effects. Hallucinations is found among people who take Hydroxyzine pamoate, especially for people who are male, 60+ old. Cetirizine, although less sedating, is non-dialyzable and possesses similar antihistamine properties. Hydroxyzine exhibits anxiolytic and sedative properties in many psychiatric patients. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking hydroxyzine: [13], Hydroxyzine can also be used for the treatment of allergic conditions, such as chronic urticaria, atopic or contact dermatoses, and histamine-mediated pruritus. Histamine can cause hives or itching on the skin. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. [48], Administration in geriatrics differs from the administration of hydroxyzine in younger patients; according to the FDA, there have not been significant studies made (2004), which include population groups over 65, which provide a distinction between elderly aged patients and other younger groups. [52] Due to their differences in molecular weight, 1 mg hydroxyzine dihydrochloride is equivalent to about 1.7 mg hydroxyzine pamoate.[53]. Note that this list is not all-inclusive and includes only common medications that may interact with hydroxyzine. INDICATIONS For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. [8][3], It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year. [8], Common side effects include sleepiness, headache, and a dry mouth. alzheimer's disease medications, such as donepezil or galantamine, anticholinergics, such as benztropine or scopolamine, antipsychotics, such as chlorpromazine, clozapine, fluphenazine, thioridazine, risperidone or trazodone, medications that can induce drowsiness, such as sleeping pills, first-generation antihistamines, muscle relaxants, most antidepressants, and anti-anxiety medications, nervous system depressants, such as barbiturates. It may also cause a serious skin reaction called acute generalized exanthematous pustulosis (AGEP), characterized by fever and a severe rash. Mechanism of Action for Hydroxyzine Hydroxyzine can also cause serious side effects such as Seizures, fainting, tremor, hallucinations, fast heart rate, chest pains, restless muscle movements ,and severe dizziness. [15][22], Because of potential for more severe side effects, this drug is on the list to avoid in the elderly.[26]. Selected from data included with permission and copyrighted by First Databank, Inc. Side effects reported with the administration of Vistaril are usually mild and transitory in nature. "[46], The Tmax of hydroxyzine is about 2.0 hours in both adults and children and its elimination half-life is around 20.0 hours in adults (mean age 29.3 years) and 7.1 hours in children. [citation needed], Hydroxyzine is rapidly absorbed and distributed with oral and intramuscular administration, and is metabolized in the liver; the main metabolite (45%), cetirizine, is formed through oxidation of the alcohol moiety to a carboxylic acid by alcohol dehydrogenase, and overall effects are observed within one hour of administration. It is not clear if elderly people are more sensitive to the effects of hydroxyzine. Central Nervous System: Drowsiness is usually transitory and may … [19] Hydroxyzine is contraindicated for intravenous (IV) injection, as it has shown to cause hemolysis. Effective at relieving itching due to allergies or dermatitis (eczema). Available as an oral capsule, oral suspension, or injectable product. I am currently on hydroxyzine and was wondering was dose might … Hydroxyzine is also used to treat allergic skin reactions such as hives or contact dermatitis. 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